In a statement, the COVID-19 EMA pandemic Task Force (COVID-ETF) has said that using chloroquine and hydroxychloroquine to treat the novel coronavirus is still being tested and the benefits of these drugs have not yet been demonstrated, but their potential side effects have.. This content does not have an English version. Other rare side effects include changes in skin pigmentation and cardiomyopathy (diseases of the heart muscle). We have summarised output from ESC meetings and journals related to this below. Some of the side effects include: Skin conditions like psoriasis or porphyria and bleaching of hair and also suffer from mild hair loss—tinnitus, which is ringing in the ear. Hydroxychloroquine is excreted in the breast milk, and it is known that infants are extremely sensitive to the toxic effects of 4-aminoquinolines. Mayo Clinic does not endorse companies or products. Plaquenil is also used for long-term treatment of autoimmune diseases such as rheumatoid arthritis (RA) and systemic lupus erythmatosis. Here, we provide a systematic review of the psychiatric side effects associated with chloroquine and hydroxychloroquine. Side Effects of Hydroxychloroquine. Hydroxychloroquine is a prescription drug used to treat many autoimmune disorders. AGEP has been associated with fever and hyperleukocytosis. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Our general interest e-newsletter keeps you up to date on a wide variety of health topics. In general, skin rash, pruritus, pigmentation disorders in skin and mucous membranes, bleaching of hair, and alopecia resolved readily when therapy was discontinued. [Ref], Rare (0.01% to 0.1%): Bone-marrow failure/depression, anemia, aplastic anemia, leukopenia, thrombocytopenia, Very rare (less than 0.01%): Agranulocytosis, Postmarketing reports: Hemolysis (in glucose-6-phosphate dehydrogenase deficient patients)[Ref], Very rare (less than 0.01%): Weight decreased/loss, fatigue/lassitude[Ref], Frequency not reported: Allergic reactions (urticaria, angioedema, bronchospasm), hypersensitivity myocarditis[Ref]. The malaria drug hydroxychloroquine, which has been promoted as a potential treatment for COVID-19, is known to have potentially serious effects on heart rhythms. Plaquenil (hydroxychloroquine) is in a class of drugs called disease-modifying anti-rheumatic drugs ( DMARDs ), which are used to decrease inflammation, pain, and joint damage. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. All rights reserved. There has been increased interest in the use of chloroquine and hydroxychloroquine in the context of COVID-19 which is currently under evaluation in trials. Your name. Though the drug was the first coronavirus treatment to be approved, the Food and Drug Administration (FDA) have since issued a warning due to the increased risk of heart problems. Sanofi Winthrop Pharmaceuticals, New York, NY. Hydroxychloroquine side effects. You may report side effects to the FDA at 1-800-FDA-1088. [Ref], Common (1% to 10%): Skin rash, pruritus, alopecia, Uncommon (0.1% to 1%): Pigmentary changes, pigmentation disorders in skin and mucous membranes, bleaching of hair, Rare (0.01% to 0.1%): Attacks of psoriasis, Very rare (less than 0.01%): Dermatitis bullous eruptions, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, drug rash with eosinophilia and systemic symptoms (DRESS) syndrome, photosensitivity, exfoliative dermatitis, acute generalized exanthematous pustulosis (AGEP), Frequency not reported: Urticaria, angioedema, Postmarketing reports: Hair color changes[Ref], Rare (0.01% to 0.1%): Exacerbation/precipitation of porphyria, Postmarketing reports: Hypoglycemia, decreased appetite, porphyria[Ref], Uncommon (0.1% to 1%): Dizziness, nerve deafness, vertigo, tinnitus, Rare (0.01% to 0.1%): Seizure/convulsions, neuromyopathy, Very rare (less than 0.01%): Nystagmus, ataxia, Postmarketing reports: Extrapyramidal disorders (e.g., dystonia, dyskinesia, tremor), deafness[Ref], Common (1% to 10%): Affect/emotional lability, Very rare (less than 0.01%): Psychosis, suicidal behavior, nightmares, Uncommon (0.1% to 1%): Abnormal liver function tests, Very rare (less than 0.01%): Fulminant hepatitis, Postmarketing reports: Acute/fulminant hepatic failure[Ref], Uncommon (0.1% to 1%): Sensorimotor disorders, Frequency not reported: Absent/hypoactive deep tendon reflexes, Postmarketing reports: Skeletal muscle myopathy/muscle weakness/neuromyopathy (leading to progressive weakness, atrophy of proximal muscle groups), depression of tendon reflexes, abnormal nerve conduction studies[Ref], Myopathy has been reversible after therapy discontinuation, but recovery has taken many months. The side effects associated with the intake of hydroxychloroquine can be short term or longterm. Last updated on Apr 26, 2020. Hydroxychloroquine Sulfate (hydroxychloroquine)." If it is being used in the context of treating the coronavirus, the short duration of therapy will likely avoid many of those. There are potential cardiovascular side effects associated with its use. In 2005, Lareb, the Netherlands Pharmacovigilance Centre, reported that it received three reports of permanent hearing loss and tinnitus after long-term Plaquenil use. Although not all of these side effects may occur, if they do occur they may need medical attention. Drug information provided by: IBM Micromedex. Taking the drug with milk can also help. Call your doctor for medical advice about side effects. Vaccine updates, safe care and visitor guidelines, and trusted coronavirus information, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, FREE book offer – Mayo Clinic Health Letter, Blistering, peeling, loosening of the skin, feeling that others are watching you or controlling your behavior, feeling that others can hear your thoughts, feeling, seeing, or hearing things that are not there, increased blinking or spasms of the eyelid, large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, and sex organs, red skin lesions, often with a purple center, sore throat sores, ulcers, or white spots on the lips or in the mouth, trouble with breathing, speaking, or swallowing, uncontrolled twisting movements of the neck, trunk, arms, or legs, numbness or tingling in the hands, feet, or lips, Continuing ringing or buzzing or other unexplained noise in the ears, feeling of constant movement of self or surroundings, unsteadiness, trembling, or other problems with muscle control or coordination. What are the side effects of hydroxychloroquine? low blood sugar --headache, hunger, sweating, irritability, dizziness, nausea, fast heart rate, and feeling anxious or shaky; or low blood cell counts --fever, chills, sore throat, weakness or ill feeling, swollen gums, mouth sores, skin sores, rapid heart rate, … Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), ASHP (updated 3 Dec 2020) and others. The most common side effects were upset stomach or nausea (25% with once-daily, 19% with twice-weekly, and 18% with once-weekly hydroxychloroquine, vs 11% for placebo), followed by diarrhea, vomiting, or abdominal pain (23% for … While hydroxychloroquine is on the World Health Organisation's list of the safest and most effective medicines needed in … Your email. Retinopathy appeared to be uncommon when the recommended daily dose was not exceeded. Retinopathy (Damage of Eyes) The most common and serious side effect of hydroxychloroquine is retinopathy. Although not all of these side effects may occur, if they do occur they may need medical attention. Prasco Laboratories, Cincinnati, OH. According to the Centers for Disease Control and Prevention, hydroxychloroquine is “a relatively well-tolerated medicine.” The most common, mild side effects such as nausea, stomach pain, headache and vomiting may be lessened by taking the drug with food, the agency said. I’ve been taking it for the last week and a half. The drug is also used in the treatment of certain immunological disorders such as rheumatoid arthritis and lupus. 1. Side Effects What are the side effects of Hydroxychloroquine (Plaquenil)?. Common side effects may include vomiting, headache, changes in vision, and muscle weakness. Applies to hydroxychloroquine: oral tablet. "Product Information. Background. Side effects of hydroxychloroquine include abnormal heart rhythms and a dangerously rapid heart rate called ventricular tachycardia. Indications, dose, contra-indications, side-effects, interactions, cautions, warnings and other safety information for HYDROXYCHLOROQUINE SULFATE. It is advisable to consult with a physician before taking a prescription to avoid overdosing which can cause the adverse effects of the drug. Hydroxychloroquine is being studied to prevent and treat coronavirus disease 2019 (COVID‑19), but all clinical trials conducted during 2020 found it is ineffective and may cause dangerous side effects. Get emergency medical help if you have signs of an allergic reaction to hydroxychloroquine (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling). This is not a complete list of side effects and others may occur. The most common side effects reported were gastrointestinal, namely, stomach upset or nausea, diarrhea, vomiting, or abdominal pain. From the FDA: “A number of fatalities have been reported following the accidental ingestion of chloroquine, sometimes in relatively small doses (0.75 g or 1 g in one 3-year-old child). although not all the side effects may not appear after using the medication. The side effect of hydroxychloroquine is numerous, which include: Damage of the eye is caused by visual problems that can be permanent, especially when taken an overdose. Overall, these … Why not just give it to everyone and monitor their outcomes? Though the drug was the first coronavirus treatment to be approved, the Food and Drug Administration (FDA) have since issued a warning due to the increased risk of heart problems. If allowed to develop, there was risk of progression even after treatment withdrawal. 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